Bioxodes meets enrollment milestone in Phase 2a intracerebral hemorrhagic stroke trial
December 19, 2024
Gosselies, Belgium
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Bioxodes’ innovative pipeline includes a clinical-stage program for the prevention of thrombosis and neuroinflammation in patients with an intracerebral hemorrhage (ICH).
Neuroinflammation plays a critical role in the neurologic decline of ICH patients. BIOX-101 (Ir-CPI), the lead drug candidate of this program, exhibits a unique mechanism of action by targeting coagulation factors (FXIIa & FXIa) and neutrophils, key driver components of the neuroinflammatory process. BIOX-101 prevents blood clot formation without increasing the bleeding risk — a major asset in ICH patients — due to the specific coagulation factors targeted by this compound.
In parallel, Bioxodes is developing a pipeline of drug candidates with the objectives to treat chronic thrombo-inflammatory and inflammatory diseases. The goal is to leverage the activity of BIOX-101 against neutrophil activation and neutrophil extracellular trap (NET) formation.
Our innovative pipeline includes a clinical-stage program with BIOX-101 (Ir-CPI) for the prevention of thrombosis and neuroinflammation in hemorrhagic stroke patients. Currently, our Phase IIa program is underway, aiming to gather safety data and initial evidence of efficacy in patients with ICH.
“Stroke is worldwide one of the main causes for mortality,” he says in this video. “We are really in need to find medication hear to try and improve their prognosis.” Professor Lemmens, the head of the stroke unit at the University Hospital Leuven (Belgium), was speaking at an investor event Bioxodes had organized in Zurich, in February 2024.
Our first-in-class drug candidate with a unique mechanism of action on neutrophils and coagulation factors (FXIa and FXIIa).
Bioxodes is building an innovative pipeline with drug candidates for the prevention of thrombo-inflammatory and inflammatory diseases.
Clinical trials are being conducted to assess the safety and efficacy of Ir-CPI with a primary focus on hemorrhagic stroke.
Bioxodes meets enrollment milestone in Phase 2a intracerebral hemorrhagic stroke trial
December 19, 2024
Gosselies, Belgium
A Tick Molecule to Rescue Lives after Intracerebral Hemorrhage
November 14, 2024
Brain Innovation Days
November 13, 2024
Brussels, Belgium
Bioxodes will participate in the Brain Innovation Days on November 13th and 14th, with our CEO, Marc Dechamps, and CMO, Hans Warrinnier, attending in person. Our CMO will present a poster titled "A Tick Saliva Molecule to Rescue Lives After Intracerebral Haemorrhage."
Six biomimicry biotech companies harnessing nature’s wisdom to develop breakthrough drug candidates
October 14, 2024
Bioxodes topped a list of six biotech companies whose medicines are derived from animals in an article in Labiotech.eu, Europe’s leading biotech news website. “Some of the most exciting therapies in the future could come from animals,” the article concluded. At Bioxodes, we couldn’t agree more! The saliva of the tick contains proteins which Bioxodes uses in its BIOX-101 therapy for hemorrhagic stroke, an often deadly condition. BIOX-101 has anti-clotting and anti-inflammatory properties, without causing further bleeding. The article also listed Celtic Biotech Ltd, which uses the venom of the rattlesnake to battle cancer, and Soricimed Biopharma Inc., whose cancer drugs are derived from the saliva of the northern short-tailed shrew, a venomous mammal from Northern America. Bioxodes is enrolling the first 16 intracerebral hemorrhagic stroke (ICH) patients in a Phase 2a study with BIOX-101, and expects interim results in the first quarter of 2025. The study is taking place across 10 stroke centres in Belgium, and is led by Prof Robin Lemmens, a world-leading stroke authority, and head of clinic at the University Hospital Leuven, UZ Leuven. Link to the full article: https://www.labiotech.eu/best-biotech/biomimicry-companies-drug-development/
Bioxodes is a Belgian private company, founded in 2013. The Company has received fundings from both the public and private investors.
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