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About us

Bioxodes is a clinical-stage biotech company developing a range of therapeutics to tackle thrombo-inflammation at its source, starting with a potential breakthrough for stroke.

Company Overview

About us

Company overview

Bioxodes takes advantage of its deep understanding of the thrombo-inflammatory events to design novel product candidates.

Our lead asset, BIOX-101, offers breakthrough hope for patients suffering from intracerebral hemorrhage (ICH), an often deadly disease for which there is no approved cure. Accounting only for about 15% of all cases of stroke, ICH is the cause of 40% of all stroke-related deaths. Surviving patients often suffer severe disabilities, with fewer than 20% achieving full functional independence after six months.

Like other recently successful drugs, BIOX-101 has its origins in nature. It is a recombinant version of a small protein found in the saliva of the tick (Ixodes ricinus). Benefiting from millions of years of evolution, the protein enables the animal to attach itself to the body of its hosts for multiple days without detection (anti-inflammation) and to feed on blood (anticoagulation). BIOX-101’s powerful dual mode of action reflects these two functions

We are currently preparing a Phase 2b trial for BIOX-101, after very encouraging interim results in a Phase 2a trial. We have started the required CMC process to produce the required amount of BIOX-101 for the trial, and expect to start recruiting the first patients in the beginning of 2027.

BIOX-101 is also in development for ischemic stroke, and an undisclosed thrombo-inflammatory indication and will serve as an exploratory development program for other thrombo- and neuro-inflammatory indications.

Bioxodes is located in the Brussels South Charleroi Biopark, Belgium.

Our Team

Management

    • Dechamps Marc

      Marc Dechamps is a biologist with more than 35 years of experience in the pharmaceutical industry, including at GSK and ViiVHealthcare. His extensive expertise in developing new products ranges from infectious diseases, immunological disorders, oncology and CNS disorders to vaccines. In 2016, Marc founded XMF consulting, a company which supports biotech and biopharma businesses with strategic advice and management leadership. He has served as managing director of Delphi Genetics, a CDMO, and interim CEO of eTheRNA Immunotherapies, an mRNA biotech firm. Next to his busy role as Bioxodes CEO, Marc serves as president of the board of Investsud Tech (group InvestSud) and as board member of HealthTech for Care (HT4C). He is a co-academic director for the advanced masters in biotech & medtech ventures at the Solvay Brussels School of Economics & Management, and recently joined Ose Immunotherapeutics as an independent board member.

    • Detrixhe Pierre

      Pierre Detrixhe is Managing Partner at Financière spin-off luxembourgeoise and Venture Director at Newton Biocapital. He brings more than 10 years of experience in the field of venture capital and has accompanied many companies in the start-up phase. Previously, he held positions of scientist and technology transfer officer in the biotechnology field. Pierre Detrixhe is Director at the Board of some promising Belgian start-up companies. He holds a Master in Bioengineering from the University of Liège (Gembloux Agro-Bio Tech), Belgium and a Master in Management from the Catholic University of Louvain, Belgium.

    • Fontaine François

      François Fontaine holds a law degree from the University of Brussels and he is a specialist in Tax affairs. He was counsel in various public institutions and cabinet. He is currently general counsel to the Federal Holding and Investment Company (SFPI)-FPIM. SFPI is focusing its investments on innovative Belgian Companies, hoping to contribute to their financial and societal success story. Mr. Fontaine is also a Board member of several companies including biotechs.

    • Croughs Thérèse

      Dr Thérèse Croughs has over 30 years of experience in the Pharma and Biotech Industry, specializing in the provision of clinical development and regulatory strategy services to manufacturers and developers of biologics and biotech products. She brings a high level of medical expertise in the fields of hematology, immunology, infectious diseases and oncology, as well as experience of clinical development in biotechnology and regulatory affairs, having taken a number of early stage compounds from preclinical studies to the clinic. Dr Croughs started her career working in R&D for Bayer, NovoNordisk and BioAlliance Pharma, Paris, before joining Cytheris and then Neovacs as CMO. Whilst there, she was responsible for all R&D development activities, including Regulatory Affairs in EU, US as well as ROW. This included the registration of Kogenate® in EU, Loramyc® (miconazole Lauriad) in FR-EU and US/Japan, together with other applications using the same drug delivery technology. She was also responsible for the management of Medical Affairs and R&D and the development of a NCE pipeline (therapies developed to target drug resistance such as small molecules in infectious diseases, gene therapy in oncology).

    • Dechamps Marc

      Marc Dechamps is a biologist with more than 35 years of experience in the pharmaceutical industry, including at GSK and ViiVHealthcare. His extensive expertise in developing new products ranges from infectious diseases, immunological disorders, oncology and CNS disorders to vaccines. In 2016, Marc founded XMF consulting, a company which supports biotech and biopharma businesses with strategic advice and management leadership. He has served as managing director of Delphi Genetics, a CDMO, and interim CEO of eTheRNA Immunotherapies, an mRNA biotech firm. Next to his busy role as Bioxodes CEO, Marc serves as president of the board of Investsud Tech (group InvestSud) and as board member of HealthTech for Care (HT4C). He is a co-academic director for the advanced masters in biotech & medtech ventures at the Solvay Brussels School of Economics & Management, and recently joined Ose Immunotherapeutics as an independent board member.

    • Le Normand Didier

      Didier Le Normand is a seasoned professional with a 40-year international career, and he has been a part-time senior consultant since 2022.

      Didier held executive positions in large international groups and private equity-backed industrial SMEs where he led operational turnarounds, supply-chain, financing and M&A transactions.

      Over the past 15 years, Didier held CFO, COO and CEO roles in biotech and medtech ventures. His focus has been on providing strategic support and governance structure as well as conducting various fundraising and transactions.

      Didier graduated (MBA) in both Paris and New York. His commitment to education is now reflected through his role as co-coordinator and lecturer for the Advanced Master in Biotech & Medtech Ventures program at the Solvay Lifelong Learning Brussels School.

    • Warrinnier Hans

      Dr. Hans Warrinnier joined Bioxodes following a leadership tenure at Roche Belgium where he held various senior leadership positions such as Medical Director. In this position, he led a team of 70+ across Clinical Operations, Medical Affairs and Medical Information, Drug Safety and Regulatory Affairs. He developed and supported affiliate and global clinical studies in different therapeutic areas, maintaining Belgium’s top spot in clinical trials per capita in the world. He delivered strategic expertise and advice for market access solutions in Belgium across different therapeutic areas, including oncology, hematology, neurology, immunology, and hemophilia. In addition to receiving his medical degree from the KU Leuven in Belgium, Dr. Warrinnier followed Business school programs from London Business School and Harvard Business School.

    • Derochette Sandrine

      Sandrine Derochette obtained her PhD in Biochemistry and Cellular and Molecular Biology from the University of Liège in 2015 (study of the effect of curcumin on oxidative response of neutrophils). After her PhD, she joined Bioxodes as Study Coordinator in 2015. She is now Project Manager and Manager of the Quality Assurance team at Bioxodes.

    • Pireaux Valérie

      Valérie Pireaux obtained her PhD in Biochemistry and Cellular and Molecular Biology (atherosclerosis specialization) from the University of Namur in 2017. After her PhD, she joined Bioxodes as Preclinical Scientist in 2017. She now holds the position of Preclinical Operations Manager & Clinical Data Reviewer.

    • Demoulin Stéphanie

      Stéphanie Demoulin obtained her PhD in Biomedical and Pharmaceutical Sciences from the University of Liège in 2014, where she conducted an in-depth study on the role of dendritic cells in the progression of cervical cancer. Following her PhD, she pursued postdoctoral research focused on the development of therapeutic approaches for breast cancer at the University of Liège.

      In 2016, Stéphanie transitioned to Bioxodes as a Scientific Writer, where she utilized her extensive research background to support the company's scientific communications. Her expertise led to her current role, where she now leads the medical writing activities for Bioxodes. In this role, she is responsible for writing key scientific documents, regulatory submissions and publications that report on the company's research and development achievements.

      In addition to her role in medical writing, Stéphanie also manages Bioxodes' Intellectual Property (IP) portfolio. This involves overseeing the identification, protection, and strategic management of the company's IP assets, ensuring that Bioxodes' innovations are safeguarded and leveraged to maximize their commercial potential.

    • Corbisier Charlotte

      Charlotte obtained her Master in Pharmaceutical Sciences in 2014. Having started her career in pharmacies, she quickly reoriented herself in the field of clinical studies. She began her career in the field of Clinical Research Organization (Medpace) where she developed the qualities needed for the successful development of a Clinical Project Manager. She worked there for 2.5 years, before starting to work as a Clinical Project Manager for a large pharmaceutical company for 3 years (Bristol Myers Squibb). She joined Bioxodes in 2021 and now holds the position of Clinical Operations Lead.

    • Hespel Cindy

      Cindy Hespel obtained her PhD in Immunology from the University of Brussels (ULB) in 2012 (Regulation of Adaptive Immune Responses by Conventional and Inflammatory Dendritic Cells). After her PhD, she began her career as Project Execution Manager (Global Medical Affairs Operations) at GlaxoSmithKline Vaccines for 2 years. She then moved to Bristol Myers Squibb as Clinical Trial-Global Submission Manager managing large portfolio across diverse Therapeutic Areas for 7 years before joining Bioxodes as Regulatory Affairs Manager in 2021.

About us

Advisory Board

  • Lemmens Robin
  • Al-Shahi Salman Rustam
  • Endres Matthias
  • Seiffge David
  • Cordonnier Charlotte
  • Vivien Denis
  • Hermans Cedric
  • Shoamanesh Ashkan
  • Selim Magdy
    • Robin Lemmens, M.D.

      01.
      Leuven, Belgium

      Robin Lemmens is a neurologist with specific certification in rehabilitation and the head of the stroke unit at the University Hospitals Leuven (Belgium). His main research interests are imaging of acute stroke focusing on the role of MRI and CT perfusion for prediction of outcome including artificial intelligence and stroke recovery. He is a fellow and member of Board of Directors of the European Stroke Organization, previous chair of ESOTA (European Stroke Organisation Trials Alliance) and vice-chair of the Belgian Stroke Council.

    • Rustam Al-Shahi Salman, MA MB BChir PhD FRCP Edin FHEA FESO

      02.
    • Matthias Endres, M.D.

      03.
    • David Seiffge, M.D.

      04.
    • Charlotte Cordonnier, M.D.

      05.
    • Denis Vivien, Ph.D

      06.
    • Cedric Hermans, M.D, Ph.D, FRCP (Lon, Edin)

      07.
    • Ashkan Shoamanesh, M.D.

      08.
    • Magdy Selim, M.D., PhD.

      09.